Sexual function is an important aspect of human life. It plays a key role in maintaining intimate relationships and reproduction. Sexual health (that is, the physical, mental, and social ability to perform activities related to intimate relationships) is significantly associated with quality of life and overall health.
Sexual dysfunction (decreased ability to experience pleasure at any stage of physical intimacy including desire, arousal, and orgasm) is usually associated with several factors. These include structural damage, disease processes, depression and other mental disorders, etc.
Regardless of the cause, modern medicines can help solve the problem successfully. You can try, for example, Cialis, Viagra, or Levitra. This article describes Cialis and the specifics of its use in treating erectile dysfunction. Take a moment to learn the information carefully and you will definitely find answers to all your questions.
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| Where to Buy Cialis? | Visit Canadian Pharmacy |
What is Cialis
Cialis online is a relatively new drug for male erectile dysfunction ED. The first publications concerning the experience of its clinical use appeared in 2001. But today, Cialis is widely accepted throughout the world as a safe and effective oral ED medication.
Cialis tadalafil is a specific reversible phosphodiesterase type 5 (PDE-5) inhibitor that inactivates cAMP and cGMP. These two substances are secondary mediators in reactions with prostacyclin and nitric oxide (NO). The rationale for the medical use of Cialis is becoming obvious. PDE5 inhibitors express the oxide pathway through inhibition of cGMP hydrolysis. An increase in cGPM concentration has vasodilating, antiproliferative, and proapoptotic effects.
Erectile Dysfuction
Male erection is a complex phenomenon. It requires smooth interaction between the nervous, vascular, and hormonal systems. In response to sexual stimulation, impulses from the frontal and temporal lobes of the cerebral hemispheres enter the amygdala (one of the most important erection centers). The impulse is then transmitted along the nerve pathways to the parasympathetic centers of the spinal cord located at the S2-S4 level.
Sexual stimulation causes a sharp predominance of parasympathetic impulses. Parasympathetic noncholinergic and nonadrenergic nerve endings release nitric oxide (the main mediator of erection). This causes relaxation of the smooth muscle cells in the corpora cavernosa, decreases peripheral arteriolar resistance, and increases arterial blood flow. An erection occurs, the penis lengthens and enlarges.
Erectile dysfunction is generally defined as the inability to achieve and maintain an erection sufficient for successful sexual intercourse. ED is an important problem affecting both the psychosocial well-being of the man and his partner. The frequency of this sexual disorder increases with age: at 40-50 years old it is detected in 40% of men, at 50-60 years old – in almost half of those examined (48-57%), and in the older age group more than 70% of men suffer from this disorder.
According to Rita C. Tostes, Fernando S. Carneiro, Anthony J. Lee et al., ED occurs 15-20% more often in smokers than in non-smoking men. And the explanation is simple. Smoking causes vascular spasms, which impede blood flow to the penis and reduce erection strength.
Can I Buy Cialis Over the Counter?
If you want to improve your sexual health, you can buy Cialis without a doctor prescription at any time. Our service consultants are always in touch and will gladly help you place an order online. However, we recommend consulting a doctor before starting treatment. You may have contraindications to using the drug. In addition, it is important to find out detailed information about the specific dosage and administration features. A healthcare provider will check your health state and answer all questions.
How Cialis Work
The mechanism of Cialis action is actually very simple. As a result of sexual stimulation, large amounts of nitric oxide are locally released in the male external genitalia (latent phase). At the same time, tadalafil inhibits PDE-5, which leads to an increase in the level of c-GMP in the corpus cavernosum of the penis. This promotes relaxation of smooth muscle structures and blood flow to the tissues, resulting in an erection (tumescence phase) sufficient for sex.
Benign prostatic hyperplasia
Many people buy Cialis to relieve symptoms of benign prostatic hyperplasia (BPH). This is a condition in which the prostate gland becomes enlarged, causing difficulty urinating. This problem is not related to cancer and is not life-threatening, but it can cause some unpleasant symptoms. The first and most common symptom of BPH is frequent urination, especially at night. Other symptoms may include painful urination, incomplete emptying of the bladder, and sometimes blood in the urine.
The exact cause of BPH is currently unknown. But research shows that changing hormone levels play a major role. Age is also a risk factor. The likelihood of developing BPH increases with age. Genetics is also important, as some men have an increased predisposition to this condition.
Regardless of the cause, Cialis helps manage benign prostatic hyperplasia quickly and effectively. By relaxing the smooth muscles of blood vessels, tadalafil leads to an increase in blood perfusion and, as a result, a decrease in the severity of unpleasant symptoms.
Generic vs Brand
A branded drug is one that was first created and introduced to the market by a specific company under a proprietary name. This medicine has proven therapeutic efficacy, safety, and quality. It has come a long way and a full cycle of preclinical and clinical studies.
When the patent on a brand-name drug expires, the pharmaceutical company has the right to produce a generic version. This medicine contains the same active substance as the original. However, excipients may differ from the original composition. This may cause changes in the taste, color, or texture but usually does not negatively affect effectiveness.
Generics are great solutions for many people. These are cheaper analogs of the original drug. However, not everyone trusts the effectiveness and safety of substitutes, even though the drugs contain the same active ingredients. The choice is yours. You can give preference to the brand or order generic Cialis without any restrictions.
Customer Reviews
- This is not the first time I have bought Cialis otc. The product works very well and gives quick results!
- I like Cialis tadalafil because it is well tolerated and does not cause side effects. I take it as needed, not every day. This is a good helper for men with erectile dysfunction.
- You can be sure that this is the best phosphodiesterase type 5 inhibitor on the modern pharmacological market. I just recently finished treatment, I feel great, my sexual function has improved significantly.
- I think Cialis works better than Viagra and Levitra. The effect appears within 16 minutes after administration and lasts for 36 hours. I’m very pleased with my choice.
Cialis Dosage
Cialis pills should be taken orally, regardless of meals. Use this medication as needed at a 10 mg dosage. Take it at least 30 minutes before sexual activity (although the initial therapeutic effect begins 16 minutes after administration). If the effect is insufficient, the single dose can be doubled. The drug is used 1 time per day. If you have repeated sexual intercourse within 24 hours, you do not need to take Cialis again because the drug remains effective for 36 hours.
If you need to take Cialis frequently (for example, once every 2-3 days), it is better to use 5 mg of the drug every day for several weeks. If the indicated dose causes a pronounced therapeutic effect, it can be reduced to 2.5 mg.
Potential Side Effects
Cialis is usually well tolerated by patients and does not cause side effects, provided dosage recommendations are followed. However, like any other drug, it has several potential side effects:
• Headache;
• Dyspepsia;
• Back pain;
• Myalgia.
The risk of these adverse reactions increases with increasing dosage.
Cialis vs Viagra
Cialis is a well-known modern medicine for treating ED and benign prostatic hyperplasia in men. It works based on tadalafil, a highly effective phosphodiesterase type 5 inhibitor. Available dosages – 5, 10, and 20 mg. The effect begins 16 minutes after administration and lasts for 36 hours. Eating does not affect effectiveness.
Viagra over the counter medication is no less popular option than Cialis. It has been used in clinical practice since 1998. The main active ingredient – sildenafil. It is used in 25, 50, and 100 mg dosages. The medicine begins to act 40-50 minutes after administration and retains the effect for about 4-6 hours. Fatty foods slow down the absorption of sildenafil, reducing its effectiveness.
Cialis vs Levitra
Levitra vardenafil is another oral medication you can use to treat erectile dysfunction. Available in 5, 10, and 20 mg dosages. The action begins in 15-25 minutes and lasts up to 8-12 hours. It’s better than Viagra, but still less effective than Cialis.
Summary
Most men with ED prefer oral medications such as phosphodiesterase type 5 (PDE5) inhibitors: tadalafil (Cialis), sildenafil (Viagra), and vardenafil (Levitra). PDE-5 suppression enhances the effects of nitric oxide, increases cyclic guanosine monophosphate in cells, and decreases Ca2+ levels. Smooth muscle relaxation causes increased arterial flow to the penis. An increase in intracavernous pressure results in an erection. Hence the high effectiveness of these drugs.
FAQ
What is Cialis good for besides ED?
Besides ED, Cialis is also good for treating benign prostatic hyperplasia.
What are the side effects of taking Cialis?
The most common side effects of taking Cialis include headache, dyspepsia, back pain, and myalgia.
How long does tadalafil 20mg last?
Tadalafil 20mg retains its effect for up to 36 hours.
What products have tadalafil in them?
Honey products contain tadalafil.