BioNTech to Present Clinical Data Updates for Personalized mRNA-based and Targeted Oncology Candidates at AACR 2024

Published March. 26. 2024

In a captivating development poised to advance the fight against cancer, BioNTech SE, a pioneer in mRNA-based therapies, unveiled a showcase of clinical trial data for select candidates from its robust oncology pipeline. The grand stage for this unveiling was set at the American Association for Cancer Research (AACR) Annual Meeting 2024, held in the vibrant city of San Diego, California, from April 5-10, 2024.

Excitement filled the air as BioNTech prepared to present data on its cutting-edge investigational mRNA-based cancer vaccine and innovative antibody-drug conjugate (ADC) approaches. These presentations, spanning both oral and poster formats, promised to shed light on groundbreaking advancements in the field of oncology.

Professor Özlem Türeci, M.D., the esteemed Co-Founder and Chief Medical Officer at BioNTech, shared insights into the company’s pioneering work. “This year’s AACR presentations feature candidates from our individualized and off-the-shelf mRNA cancer vaccine platforms,” remarked Prof. Türeci. “Our investigational mRNA cancer vaccine approaches are an important pillar in our oncology portfolio, aimed at eliminating residual tumor foci and reducing the tumor burden by targeting multiple antigens at once.”

One of the highlights of BioNTech’s presentation was the unveiling of longer-term follow-up data from the investigator-initiated Phase 1 trial with the mRNA-based individualized neoantigen-specific immunotherapy (iNeST) candidate, autogene cevumeran (BNT122, RO7198457), in patients with resected pancreatic ductal adenocarcinoma (PDAC). This groundbreaking trial, published in Nature, showcased promising results that underscored the potential of mRNA-based therapies in combating pancreatic cancer.

Another riveting revelation came in the form of preliminary results from the LuCa-MERIT-1 Phase 1 trial with BioNTech’s off-the-shelf mRNA therapeutic cancer vaccine candidate, BNT116, in combination with docetaxel. The data exhibited encouraging signs of antitumor activity and immune response induction in patients with advanced non-small cell lung cancer (NSCLC), offering hope for those battling this challenging disease.

Furthermore, BioNTech provided insights into its ongoing global Phase 1/2a trial of the topoisomerase-1 inhibitor-based ADC candidate, BNT324/DB-1311, targeting the immune checkpoint protein B7H3 in patients with pretreated advanced or metastatic solid tumors. This innovative approach represents a promising avenue in the quest to develop effective treatments for solid tumors.

With a diversified clinical oncology pipeline comprising over 20 clinical programs, BioNTech is at the forefront of oncology research and development. As the company continues to advance its key programs into late-stage development, the horizon brims with potential, offering hope to millions affected by cancer worldwide.

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